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- Title
Intravoxel incoherent motion MR imaging of early cervical carcinoma: correlation between imaging parameters and tumor-stroma ratio.
- Authors
Park, So Hyun; Lee, Seung Soo; Sung, Ji-Youn; Na, Kiyong; Kim, Hyoung Jung; Kim, So Yeon; Park, Beom Jin; Byun, Jae Ho; Li, Xiangsheng; Wang, Ping; Li, Dechang; Zhu, Hongxian; Meng, Limin; Song, Yunlong; Xie, Lizhi; Zhu, Jianping; Yu, Tao
- Abstract
<bold>Objectives: </bold>To investigate if intravoxel incoherent motion (IVIM) MR imaging can predict the tumour-stroma ratio (TSR) in patients with early cervical carcinoma.<bold>Methods: </bold>Fifty-four patients with early cervical carcinoma were prospectively enrolled into this study. All patients underwent IVIM imaging and parameters including D, D* and f value were measured. The tumours were classified into stroma-rich and stroma-poor group according to TSR, and comparisons of IVIM parameters between two groups were performed. The relationships between IVIM parameters and TSR were analysed by using a multivariate multi-regression analysis.<bold>Results: </bold>D and f values were significantly lower in stroma-poor tumours than in stroma-rich tumours (p=0.02, 0.04), while the difference in D* value between two groups didn't achieve statistical significance (p=0.09). The areas under ROC curves of D and f values in discriminating stroma-rich and stroma-poor tumours were 0.835 (95%CI=0.616~0.905) and 0.686 (95%CI=0.575~0.798). In multiple linear regression analysis, D value, pathologic type, histologic grade, tumour size and f value were independently correlated with TSR of cervical carcinoma.<bold>Conclusions: </bold>D and f values are independently correlated with TSR of cervical carcinoma and have the potential for quantitative measurement of TSR.<bold>Key Points: </bold>• TSR is a recognized independent prognostic factor in many solid tumours. • D and f values measured by IVIM MRI are independently correlated with TSR while D* is not. • IVIM offers the potential to predict TSR.
- Subjects
ULTRASONIC imaging; ELASTOGRAPHY; LIVER diseases; LIVER transplantation; HISTOPATHOLOGY; CERVIX uteri tumors; ANIMAL experimentation; CERVIX uteri; DIFFERENTIAL diagnosis; MAGNETIC resonance imaging; TUMOR classification; CONTRAST media; RECEIVER operating characteristic curves; EARLY diagnosis; DIAGNOSIS
- Publication
European Radiology, 2018, Vol 28, Issue 5, p2096
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-017-5183-3