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- Title
Diagnostic accuracy of transabdominal high-resolution US for staging gallbladder cancer and differential diagnosis of neoplastic polyps compared with EUS.
- Authors
Lee, Jeong; Kim, Jung; Kim, Yong; Ryu, Ji; Kim, Yong-Tae; Lee, Jae; Han, Joon; Lee, Jeong Sub; Kim, Jung Hoon; Kim, Yong Jae; Ryu, Ji Kon; Lee, Jae Young; Han, Joon Koo
- Abstract
<bold>Purpose: </bold>To compare the diagnostic accuracy of transabdominal high-resolution ultrasound (HRUS) for staging gallbladder cancer and differential diagnosis of neoplastic polyps compared with endoscopic ultrasound (EUS) and pathology.<bold>Materials and Methods: </bold>Among 125 patients who underwent both HRUS and EUS, we included 29 pathologically proven cancers (T1 = 7, T2 = 19, T3 = 3) including 15 polypoid cancers and 50 surgically proven polyps (neoplastic = 30, non-neoplastic = 20). We reviewed formal reports and assessed the accuracy of HRUS and EUS for diagnosing cancer as well as the differential diagnosis of neoplastic polyps. Statistical analyses were performed using chi-square tests.<bold>Results: </bold>The sensitivity, specificity, PPV, and NPV for gallbladder cancer were 82.7 %, 44.4 %, 82.7 %, and 44 % using HRUS and 86.2 %, 22.2 %, 78.1 %, and 33.3 % using EUS. HRUS and EUS correctly diagnosed the stage in 13 and 12 patients. The sensitivity, specificity, PPV, and NPV for neoplastic polyps were 80 %, 80 %, 86 %, and 73 % using HRUS and 73 %, 85 %, 88 %, and 69 % using EUS. Single polyps (8/20 vs. 21/30), larger (1.0 ± 0.28 cm vs. 1.9 ± 0.85 cm) polyps, and older age (52.5 ± 13.2 vs. 66.1 ± 10.3 years) were common in neoplastic polyps (p < 0.05).<bold>Conclusion: </bold>Transabdominal HRUS showed comparable accuracy for diagnosing gallbladder cancer and differentiating neoplastic polyps compared with EUS. HRUS is also easy to use during our routine ultrasound examinations.<bold>Key Points: </bold>• HRUS showed comparable diagnostic accuracy for GB cancer compared with EUS. • HRUS and EUS showed similar diagnostic accuracy for differentiating neoplastic polyps. • Single, larger polyps and older age were common in neoplastic polyps. • HRUS is less invasive compared with EUS.
- Subjects
GALLBLADDER cancer; TUMOR grading; POLYPS; ULTRASONIC imaging of cancer; DIFFERENTIAL diagnosis; ENDOSCOPIC ultrasonography; GALLBLADDER diseases; PRECANCEROUS conditions; GALLBLADDER tumors; COMPARATIVE studies; RESEARCH methodology; MEDICAL cooperation; RESEARCH; RESEARCH evaluation; TUMOR classification; ULTRASONIC imaging; EVALUATION research; DIAGNOSIS
- Publication
European Radiology, 2017, Vol 27, Issue 7, p3097
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-016-4646-2