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- Title
Image quality, radiation dose and diagnostic accuracy of 70 kVp whole brain volumetric CT perfusion imaging: a preliminary study.
- Authors
Fang, Xiao; Ni, Qian; Schoepf, U.; Zhou, Chang; Chen, Guo; Luo, Song; Fuller, Stephen; Cecco, Carlo; Zhang, Long; Lu, Guang; Fang, Xiao Kun; Ni, Qian Qian; Schoepf, U Joseph; Zhou, Chang Sheng; Chen, Guo Zhong; Fuller, Stephen R; De Cecco, Carlo N; Zhang, Long Jiang; Lu, Guang Ming
- Abstract
<bold>Purpose: </bold>To evaluate image quality and diagnostic accuracy for acute infarct detection and radiation dose of 70 kVp whole brain CT perfusion (CTP) and CT angiography (CTA) reconstructed from CTP source data.<bold>Methods: </bold>Patients were divided into three groups (n = 50 each): group A, 80 kVp, 21 scanning time points; groups B, 70 kVp, 21 scanning time points; group C, 70 kVp, 17 scanning time points. Objective and subjective image quality of CTP and CTA were compared. Diagnostic accuracy for detecting acute infarct and cerebral artery stenosis ≥ 50 % was calculated for CTP and CTA with diffusion weighted imaging and digital subtraction angiography as reference standards. Effective radiation dose was compared.<bold>Results: </bold>There were no differences in any perfusion parameter value between three groups (P > 0.05). No difference was found in subjective image quality between three groups (P > 0.05). Diagnostic accuracy for detecting acute infarct and vascular stenosis showed no difference between three groups (P > 0.05). Compared with group A, radiation doses of groups B and C were decreased by 28 % and 37 % (both P < 0.001), respectively.<bold>Conclusion: </bold>Compared with 80 kVp protocol, 70 kVp brain CTP allows comparable vascular and perfusion assessment and lower radiation dose while maintaining high diagnostic accuracy in detecting acute infarct.<bold>Key Points: </bold>• 70 kVp whole brain CTP can provide diagnostic image quality. • 70 kVp CTP diagnostic accuracy was maintained vs. 80 kVp protocol. • 70 kVp CTP radiation doses were lower than 80 kVp protocol.
- Subjects
INFARCTION; RADIATION doses; COMPUTED tomography; ANGIOGRAPHY; ANTERIOR cerebral artery; MAGNETIC resonance angiography; STENOSIS; CEREBRAL arterial diseases; BRAIN; COMPARATIVE studies; DIAGNOSTIC imaging; RESEARCH methodology; MEDICAL cooperation; COMPUTERS in medicine; PERFUSION; RADIONUCLIDE imaging; RESEARCH; SPIRAL computed tomography; EVALUATION research; RANDOMIZED controlled trials; DIAGNOSIS
- Publication
European Radiology, 2016, Vol 26, Issue 11, p4184
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-016-4225-6