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- Title
Preoperative staging of non-small cell lung cancer: prospective comparison of PET/MR and PET/CT.
- Authors
Lee, Sang; Goo, Jin; Park, Chang; Yoon, Soon; Paeng, Jin; Cheon, Gi; Kim, Young; Park, Young; Lee, Sang Min; Goo, Jin Mo; Park, Chang Min; Yoon, Soon Ho; Paeng, Jin Chul; Cheon, Gi Jeong; Kim, Young Tae; Park, Young Sik
- Abstract
<bold>Objectives: </bold>To prospectively compare the accuracies of PET/MR and PET/CT in the preoperative staging of non-small cell lung cancer (NSCLC).<bold>Methods: </bold>Institutional review board approval and patients' informed consents were obtained. 45 patients with proven or radiologically suspected lung cancer which appeared to be resectable on CT were enrolled. PET/MR was performed for the preoperative staging of NSCLC followed by PET/CT without contrast enhancement on the same day. Dedicated MR images including diffusion weighted images were obtained. Readers assessed PET/MR and PET/CT with contrast-enhanced CT. Accuracies of PET/MR and PET/CT for NSCLC staging were compared.<bold>Results: </bold>Primary tumour stages (n = 40) were correctly diagnosed in 32 patients (80.0 %) on PET/MR and in 32 patients (80.0 %) on PET/CT (P = 1.0). Node stages (n = 42) were correctly determined in 24 patients (57.1 %) on PET/MR and in 22 patients (52.4 %) on PET/CT (P = 0.683). Metastatic lesions in the brain, bone, liver, and pleura were detected in 6 patients (13.3 %). PET/MR missed one patient with pleural metastasis while PET/CT missed one patient with solitary brain metastasis and two patients with pleural metastases (P = 0.480).<bold>Conclusions: </bold>This study demonstrated that PET/MR in combination with contrast-enhanced CT was comparable to PET/CT in the preoperative staging of NSCLC while reducing radiation exposure.<bold>Key Points: </bold>• PET/MR can be comparable to PET/CT for preoperative NSCLC staging. • PET/MR and PET/CT show excellent correlation in measuring SUVmax of primary lesions. • Using PET/MR, estimated radiation dose can decrease by 31.1 % compared with PET/CT.
- Subjects
POSITRON emission tomography; MAGNETIC resonance imaging; NON-small-cell lung carcinoma; PREOPERATIVE care; PATIENTS
- Publication
European Radiology, 2016, Vol 26, Issue 11, p3850
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-016-4255-0