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- Title
The relationship between lung function impairment and quantitative computed tomography in chronic obstructive pulmonary disease.
- Authors
Mets OM; Murphy K; Zanen P; Gietema HA; Lammers JW; van Ginneken B; Prokop M; de Jong PA; Mets, O M; Murphy, K; Zanen, P; Gietema, H A; Lammers, J W; van Ginneken, B; Prokop, M; de Jong, P A
- Abstract
<bold>Objectives: </bold>To determine the relationship between lung function impairment and quantitative computed tomography (CT) measurements of air trapping and emphysema in a population of current and former heavy smokers with and without airflow limitation.<bold>Methods: </bold>In 248 subjects (50 normal smokers; 50 mild obstruction; 50 moderate obstruction; 50 severe obstruction; 48 very severe obstruction) CT emphysema and CT air trapping were quantified on paired inspiratory and end-expiratory CT examinations using several available quantification methods. CT measurements were related to lung function (FEV(1), FEV(1)/FVC, RV/TLC, Kco) by univariate and multivariate linear regression analysis.<bold>Results: </bold>Quantitative CT measurements of emphysema and air trapping were strongly correlated to airflow limitation (univariate r-squared up to 0.72, p < 0.001). In multivariate analysis, the combination of CT emphysema and CT air trapping explained 68-83% of the variability in airflow limitation in subjects covering the total range of airflow limitation (p < 0.001).<bold>Conclusions: </bold>The combination of quantitative CT air trapping and emphysema measurements is strongly associated with lung function impairment in current and former heavy smokers with a wide range of airflow limitation.
- Publication
European Radiology, 2012, Vol 22, Issue 1, p120
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-011-2237-9