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- Title
Evaluation of oxidative stress markers in first trimester for assessment of preeclampsia risk.
- Authors
Genc, Habibe; Uzun, Hafize; Benian, Ali; Simsek, Gönül; Gelisgen, Remise; Madazli, Rıza; Güralp, Onur
- Abstract
Aim: The aim of this study is to determine the predictive values of oxidative stress markers and antioxidants in the development of preeclampsia between 10-14 and also at 20-24 weeks of gestation, after the completion of vascular transformation. Materials and methods: Levels of oxidative stress parameters such as malondialdehyde (MDA), lipidhydroperoxide (LHP) and prostaglandin F (PGF), oxidized LDL (oxLDL), and antioxidant status parameters such as paraoxonase 1 (PON1), superoxide dismutase (SOD) and total antioxidant capacity (TAC) levels were measured and compared in 21 preeclamptic and 24 healthy pregnant women. Results: In preeclamptic women, both between 10-14 and also at 20-24 weeks of gestation the levels of oxLDL, MDA and PGF were significantly higher ( P < 0.001, P < 0.001, respectively), PON1, SOD and TAC were significantly lower ( P < 0.01, P < 0.001, P < 0.05, respectively) compared to healthy pregnant women; yet there was no significant difference in LHP levels. Conclusion: Increased levels of serum MDA and PGF, low levels of SOD and PON1 activity, in 10-14 GW may have been associated with preeclampsia etiology. High levels of MDA and PGF indicate that the oxidative damage is present well before the clinical symptoms occur. A panel of oxidative stress markers such as MDA and PGF in maternal blood can predict the development of preeclampsia long before clinical onset.
- Subjects
RISK factors of preeclampsia; FIRST trimester of pregnancy; OXIDATIVE stress; ANTIOXIDANTS; BIOMARKERS; MALONDIALDEHYDE; PROSTAGLANDINS; PARAOXONASE; SUPEROXIDE dismutase
- Publication
Archives of Gynecology & Obstetrics, 2011, Vol 284, Issue 6, p1367
- ISSN
0932-0067
- Publication type
Article
- DOI
10.1007/s00404-011-1865-2