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- Title
Effect of New Quinolones on Drug-Metabolizing Enzyme System of Rat Hepatic Microsomes.
- Authors
Okazaki, Osamu; Kurata, Tadashi; Tachizawa, Haruo
- Abstract
Effects of repeated oral administration of new quinolones, ofloxacin, enoxacin and norfloxacin, once daily for 7 days, on the drug-metabolizing enzyme system of rat hepatic microsomes were studied in comparison with that of phenobarbital, a potent inducer of cytochromes P-450. Treatment of phenobarbital at the oral dose of 120 mg/kg induced significant increases in the contents of cytochrome P-450, cytochrome b5 and NADPH-cytochrome P-450 reductase and in the activity of ethoxycou-marin O-deethylase, and significant decreases in the activities of benzphetamine N-de-methylase and aniline hydroxylase. However, ofloxacin, enoxacin and norfloxacin at the oral dose levels of 80 and 320 mg/kg showed no significant effect on the content of each constituent of the drug-metabolizing enzyme system, and the three enzyme activities. Thus, it is concluded that new quinolones including ofloxacin have no ability to induce a cytochrome-P-450-dependent monooxygenase system. Copyright © 1988 S. Karger AG, Basel
- Publication
Chemotherapy (0009-3157), 1988, Vol 34, Issue 2, p149
- ISSN
0009-3157
- Publication type
Article
- DOI
10.1159/000238562