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- Title
Combined Action of Sulphamethoxazole and Trimethoprim Against Clinically-Isolated Sulphonamide-Resistant Bacteria.
- Authors
Grey, Daphne; Hamilton-Miller, J.M.T.; Brumfitt, W.
- Abstract
42 strains of gram-negative bacteria, isolated from clinical material, resistant to trimethoprim (TM), sulphamethoxazole (SMZ) or both, have been tested for synergistic sensitivity to TM + SMZ. The combination showed no synergy against strains 'highly resistant' to SMZ (MIC > 1 mg/ml). Indifference was invariably observed. However, synergy was seen with strains 'moderately resistant' to SMZ (MIC 100-1,000 ug/ml). Our results indicate that present techniques for the testing of urinary tract isolates for sensitivity to co-trimoxazole need revision. Copyright © 1979 S. Karger AG, Basel
- Publication
Chemotherapy (0009-3157), 1979, Vol 25, Issue 5, p296
- ISSN
0009-3157
- Publication type
Article
- DOI
10.1159/000237854