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- Title
Glycoxidative modification of AA amyloid deposits in renal tissue.
- Authors
Uesugi, Noriko; Sakata, Noriyuki; Nagai, Ryoji; Jono, Tadashi; Horiuchi, Seikoh; Takebayashi, Shigeo
- Abstract
Background. Nɛ-carboxymethyllysine (CML) is a product of the oxidative modification of glycated proteins, which damages proteins with ageing, diabetes, uraemia and Alzheimer's disease. In contrast, pyrraline is one of the advanced glycation end products, which is independent of oxidative processes. CML has been identified in β-amyloid of Alzheimer's disease and β2-microglobulin-associated amyloid. We investigated whether CML and pyrraline are formed in AA and AL amyloid of the kidney.
- Publication
Nephrology Dialysis Transplantation, 2000, Vol 15, Issue 3, p355
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/15.3.355