We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Effects of benzylpenicillin on Streptococcus pyogenes during the postantibiotic phase in vitro.
- Authors
Odenholt, Inga; Holm, Stig E.; Cars, Otto; Odenholt, I; Holm, S E; Cars, O
- Abstract
A postantibiotic effect (PAE) for Ml2, PI800 was induced by 10 × MIC of benzylpenicillin for 2 h . The PAE was found to be 2·4 h (range 1·75–3.0 h). No incorporation of H-thymidine by the streptococci occurred during the first hours of the postantibiotic phase (PA-phase), indicating that bacterial cell division was inhibited during this period. However, these bacteria showed the same killing rate as previously unexposed control cultures when 10 × MIC of benzylpenicillin was added during the PA-phase. When bacteria in PA-phase were re-exposed to penicillin at a concentration of 0·2 × MIC multiplication of the bacteria was inhibited for 6–7 h, while at a concentration of 0·3 × MIC slow killing was induced. In contrast, previously untreated controls exposed to 0·2 × MIC and 0·3 × MIC showed a growth rate corresponding to that of bacteria grown in the absence of penicillin. The effects of subinhibitory concentrations on streptococci previously exposed to penicillin may therefore be a more important factor in determining dosage intervals than the PAE.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1989, Vol 24, Issue 2, p147
- ISSN
0305-7453
- Publication type
journal article