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- Title
Adaptation of methicillin-resistant Staphylococcus aureus during antibiotic therapy.
- Authors
Menzies, R. E.; Coroere, B. M.; MacCulloch, D.; Cornere, B M
- Abstract
Colonization of a patient by methicillin-resistant Staphylococcus aureus (MRSA) of a single phage-type for over four years is described. During this period we observed the appearance and disappearance of resistance to erythromycin, clindamycin, gentamicin, kanamycin, tobramycin, neomycin and mupirocin. We also saw stepwise increases in methicillin resistance and reversible changes in physical appearance and the colonizer pathogen role. Correlation of clinical observations, details of antibiotic therapy and laboratory studies demonstrated that adaptation of MRSA during antibiotic therapy favoured MRSA establishment and predominance.
- Subjects
ANTIBIOTICS; BACTERIOPHAGE typing; DRUG resistance in microorganisms; FATTY acids; GENES; HYDROLASES; METHICILLIN; MICROBIAL sensitivity tests; MUPIROCIN; GENETIC mutation; STAPHYLOCOCCAL diseases; STAPHYLOCOCCUS aureus; PHARMACODYNAMICS
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1989, Vol 23, Issue 6, p923
- ISSN
0305-7453
- Publication type
journal article