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- Title
Comparative in-vitro activity of moxalactam and cefotaxime against isolates from blood culture.
- Authors
Ramirez-Ronda, Carlos H.; Nevarez, Minerva; Saavedra, Sonia; Bermudez, Ramon H.; Ramirez-Ronda, C H; Nevarez, M; Saavedra, S; Bermudez, R H
- Abstract
The activity of moxalactam (LY-127935) was compared with that of cefotaxime (HR 756) and also with the activity of six cephalosporins and three aminoglycosides against clinical isolates recovered from blood cultures, including facultative Gram-negative bacilli, , coagulase-negative staphylococci and . There were 51 multiresistant strains of Grain-negative bacilli. Moxalactam was the least active of the study antibiotics against . and coagulase-negative staphylococci (with MICs of 8 mg/l and 32 mg/l, respectively). Cefotaxime was similar in activity as other cephalosporins against these organisms (MICs of 2 mg/l or less). None of the antibiotics was effective against . Moxalactam and cefotaxime were the most active drugs for all Gram-negative bacilli recovered from blood cultures and comparable in activity. MICs of 0·5 mg/l or less were found for the spp., spp., spp., spp., and Salmonellae studied. Concentrations of 32 mg/l of moxalactam inhibited 90% of spp. studied. Concentrations of cefotaxime of 16 mg/l or less inhibited 100% of the spp.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1981, Vol 7, Issue 6, p629
- ISSN
0305-7453
- Publication type
journal article