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- Title
Microcalorimetric investigation of the action of cinoxacin against Escherichia coli.
- Authors
Mårdh, P.-A.; Arhammer, M.; Colleen, S.; Andersson, K.-E.
- Abstract
The heat effects produced by a culture of exposed to cinoxacin were registered by a flow microcalorimeter of the heat conduction type. The drug decreased and delayed the heat effects. There was a late, second increase in the heat effects, which was due to selection of cinoxacin-resistant mutants. The organisms used had a MIC of 1.7 μg/ml, whereas the organisms recovered after approximately 17 h exposure to cinoxacin had a MIC of 400 μg/ml. Formation of highly elongated bacterial cells occurred within an hour after the introduction of the drug. After 5 h, lysis of the elongated cells was found. There was a correlation between the heat effects evolved and the number of colony forming units/ml.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1978, Vol 4, Issue 1, p73
- ISSN
0305-7453
- Publication type
journal article