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- Title
ELF5 Suppresses Estrogen Sensitivity and Underpins the Acquisition of Antiestrogen Resistance in Luminal Breast Cancer
- Authors
Kalyuga, Maria; Gallego-Ortega, David; Lee, Heather J.; Roden, Daniel L.; Cowley, Mark J.; Caldon, C. Elizabeth; Stone, Andrew; Allerdice, Stephanie L.; Valdes-Mora, Fatima; Launchbury, Rosalind; Statham, Aaron L.; Armstrong, Nicola; Alles, M. Chehani; Young, Adelaide; Egger, Andrea; Au, Wendy; Piggin, Catherine L.; Evans, Cara J.; Ledger, Anita; Brummer, Tilman
- Abstract
The transcription factor ELF5 is responsible for gene expression patterning underlying molecular subtypes of breast cancer and may mediate acquired resistance to anti-estrogen therapy.
- Subjects
ESTROGEN; ESTROGEN antagonists; BREAST cancer; IMMUNOPRECIPITATION; GENE expression; CANCER prognosis
- Publication
PLoS Biology, 2012, Vol 10, Issue 12, p1
- ISSN
1544-9173
- Publication type
Article
- DOI
10.1371/journal.pbio.1001461