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- Title
Peptidoglycan recognition proteins: modulators of the microbiome and inflammation.
- Authors
Royet, Julien; Gupta, Dipika; Dziarski, Roman
- Abstract
All animals, including humans, live in symbiotic association with microorganisms. The immune system accommodates host colonization by the microbiota, maintains microbiota-host homeostasis and defends against pathogens. This Review analyses how one family of antibacterial pattern recognition molecules - the peptidoglycan recognition proteins - has evolved a fascinating variety of mechanisms to control host interactions with mutualistic, commensal and parasitic microorganisms to benefit both invertebrate and vertebrate hosts.
- Subjects
PEPTIDOGLYCANS; MICROORGANISMS; PROTEINS; HOMEOSTASIS; PATHOGENIC microorganisms
- Publication
Nature Reviews Immunology, 2011, Vol 11, Issue 12, p837
- ISSN
1474-1733
- Publication type
journal article
- DOI
10.1038/nri3089