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- Title
TGFβ signalling in control of T-cell-mediated self-reactivity.
- Authors
Rubtsov, Yuri P.; Rudensky, Alexander Y.
- Abstract
In the immune system, transforming growth factor-β (TGFβ) affects multiple cell lineages by either promoting or opposing their differentiation, survival and proliferation. Understanding the cellular mechanisms of TGFβ-mediated regulation is complicated due to a broad distribution of TGFβ receptors on the surface of different immune-cell types. Recent studies using in vivo genetic approaches revealed a critical role for TGFβ signalling in T cells in restraining fatal autoimmune lesions. Here, we review recent advances in our understanding of a role for TGFβ signalling in the regulation of T-cell differentiation in the thymus and in the periphery, with a particular emphasis on TGFβ-mediated control of self-reactive T cells.
- Subjects
TRANSFORMING growth factors; T cells; CELL differentiation; THYMUS; AUTOIMMUNE diseases; IMMUNE system
- Publication
Nature Reviews Immunology, 2007, Vol 7, Issue 6, p443
- ISSN
1474-1733
- Publication type
Article
- DOI
10.1038/nri2095