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- Title
多肽金纳米粒 P12 在小鼠体内的生物安全性研究.
- Authors
刘夏荔; 马惠强; 黄凯峰; 姬宇婷; 杨红
- Abstract
To investigate the biosafety of peptide gold nanoparticles P12 administered via airway in mice. With 125 nmol/L P12 as the initial concentration, the maximum tolerated dose of P12 was confirmed by one-week observing of the daily clinical signs and body mass changes in the mice after airway administration of increasing doses of P12 by the dose-escalation method. The acute toxicity of P12 was further evaluated by observing the changes of blood routine examination, blood biochemical indices, organ coefficients and histopathological signs in mice 24 hours after the administration of 50 μLof therapeutic dose (500 nmol/L) and high dose (2 μmol/L) of P12 via airway so as to assess the in vivo safety of P12. Within 1 week of administration, the mice administered at doses up to 4 times the therapeutic dose showed normal clinical signs while no greater than 15% decrease in body mass. After 24 h of airway administration of therapeutic doses or high doses of P12, the mice showed no significant changes in organ coefficients, blood routine examination, blood biochemical indices and histopathological signs of the major organs. The maximum tolerated dose of P12 via the mouse airway is much higher than the therapeutic dose, and thus P12 proves its high biosafety.
- Publication
Chinese Medical Equipment Journal, 2022, Vol 43, Issue 9, p18
- ISSN
1003-8868
- Publication type
Article
- DOI
10.19745/j.1003-8868.2022181