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- Title
A facile iron catalyzed cross-coupling reaction under micro-flow conditions.
- Authors
Machitani, Koji; Tanaka, Yoshie; Nishiyama, Yasuhiro; Fujii, Akira; Saito, Akane; Mori, Hajime
- Abstract
The iron-catalyzed cross-coupling reaction between an aromatic Grignard reagent and a haloalkane was investigated under micro-flow conditions. The reaction proceeded smoothly by the separate feeding of the substrate solutions to give the desired cross-coupling product. Compared to the previously reported batch reaction, the effect of additives was more predominant in the micro-flow reaction. The flow reactor system appears to contribute to the stabilization and rapid trapping of the unstable catalytic species.
- Subjects
GRIGNARD reagents; IRON; ADDITIVES
- Publication
Journal of Flow Chemistry, 2020, Vol 10, Issue 3, p491
- ISSN
2062-249X
- Publication type
Article
- DOI
10.1007/s41981-020-00091-9