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- Title
FADS2 rs3834458 基因多态性与中国汉族人群冠心病易感性的相关性研究.
- Authors
徐颖誉; 赵真真; 刘守胜; 肖颖朴; 苗梦媛; 辛永宁
- Abstract
Objective: To investigate the relationship between the polymorphism of fatty acid desaturase 2 (FADS2) rs3834458 and susceptibility to coronary artery disease. Methods: 149 unrelated bloody health examinations in the Han population of Qingdao were randomly selected as the control group and 192 patients with coronary artery disease admitted to our hospital were randomly selected as the coronary artery disease group. PCR was used to genotype FADS2 rs3834458 in both groups. At the same time, the clinical data of were collected, and the biochemical indexes were tested. The above data were analyzed by t test, Wilcoxon rank sum test, chi-square test and Logistic regression. Results: The male proportion, Age, Body mass index( BMI), blood glucose (GLU), total cholesterol (TC),triglycerides (TG), low-density lipoprotein (LDL-C), alanine aminotransferase (ALT), aspartate aminotransferase (AST), gammon-glutamyl transferase (GGT), alkaline phosphatase (ALP) of coronary artery disease group were all higher than those of healthy control group (P<0.05), while the level of high-density lipoprotein (HDL-C) was significantly lower than that of the control group(P<0.05). There was no significant difference in the genotype distribution and allele frequency between the two groups(P>0.05). Gender (male), age, GLU, TC and HDL-C (<1.00 mmol/L) were independent risk factors for coronary artery disease group (OR=3.57, 1.14, 1.34, 3.50, 2.89). FADS2 rs3834458 has three genotypes: T/T, T/del, del/del, and the T allele is not an independent risk factor for coronary artery disease (P=0.641). Conclusion: There was no significant correlation between FADS2 rs3834458 polymorphism and the risk of coronary artery disease in Chinese Han population
- Subjects
QINGDAO (China); FATTY acid desaturase; CORONARY disease; BODY mass index; ALANINE aminotransferase; ASPARTATE aminotransferase
- Publication
Progress in Modern Biomedicine, 2019, Vol 19, Issue 22, p4348
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2019.22.032