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- Title
光动力疗法联合复方倍他米松对增生性瘢痕患者负性情绪和瘢痕组织p-STAT3、Egr-1表达的影响.
- Authors
田梦; 叶志梅; 徐晓静; 范波; 朱晓海
- Abstract
Objective: To investigate the clinical efficacy of photodynamic therapy combined with local blocking of compound betamethasone injection in the treatment of hypertrophic scar (HS) and its influence on patients'negative emotions and expression of scar tissue tyrosine phosphorylation STAT3 (p-STAT3) and early growth factor (Egr-1). Methods: total of 118 patients with HS, who were treated in Changzheng Hospital Affiliated to Naval Military Medical University of the PLA from January 2016 to June 2017, were selected and were randomly divided into control group (n=59) and study graoup (n=59). The control group was treated with compound betamethasone injection, and the research group was treated with photodynamic therapy on the basis of the control group's therapy.After four months of treatment, the clinical efficacy, epilepsy score, negative emotions,expression of scar tissue p-STAT3 and Egr-1 were compared between the two groups, and the occurrence of adverse reactions during the treatment of the two groups were recorded. Results: After treatment, the total effective rate [81.36% (48/59)] of the study group was significantly higher than that[54.24% (32/59)] of the control group (P<0.05); the scores of Vancouver Scar Rating Scale (VSS) and University of North Carolina Scar Rating Scale (UCSC) declined with time, and the scores of the study group were lower than those of the control group(P<0.05). The Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS) scores in the two groups 1 year after treatment were lower than those before treatment, and the scores in the study group were lower than those in the control group (P<0.05). The expression of scar tissue p-STAT3 and Egr-1 in the two groups 1 month after treatment was lower than that before treatment, and the expression in the study group was lower than that in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups during treatment( P>0.05). Conclusion: Photodynamic therapy combined with local blocking of compound betamethasone injection for HS is safe and effective. It can effectively improve scar symptoms, alleviate the negative emotions of patients, and reduce the expression of p-STAT3 and Egr-1 in epileptic tissues.
- Subjects
UNIVERSITY of North Carolina (System); HYPERTROPHIC scars; SCARS; PHOTODYNAMIC therapy; GROWTH factors; RESEARCH teams; POLYPOIDAL choroidal vasculopathy; BETAMETHASONE
- Publication
Progress in Modern Biomedicine, 2019, Vol 19, Issue 21, p4036
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2019.21.008