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- Title
Thyroid nodules with minimal cystic changes have a low risk of malignancy.
- Authors
Dong Gyu Na; Ji-hoon Kim; Dae Sik Kim; Soo Jin Kim
- Abstract
Purpose: The goal of this study was to determine the risk of malignancy of thyroid nodules with minimal cystic changes. Methods: A total of consecutive 1,000 thyroid nodules (≤1 cm) with final diagnoses from two institutions were included in this study. The risk of malignancy of thyroid nodules was analyzed according to the internal content, which was categorized as purely solid, minimally cystic (cystic changes ≥10%), and partially cystic (cystic changes >10%). We also assessed the risk of malignancy of nodules with minimal cystic changes depending on echogenicity and presence of any suspicious ultrasonografic (US) features. Results: The overall frequency of purely solid, minimally cystic, and partially cystic nodules was 730/1,000 (73%), 61/1,000 (6.1%), and 209/1,000 (20.9%), respectively, with risks of malignancy of 14.8% (108/730), 3.3% (2/61), and 3.3% (7/209), respectively. The risk of malignancy of nodules with minimal cystic changes was significantly lower than that of purely solid nodules (P=0.013). The risk of malignancy of nodules with minimal cystic changes was also lower than that of purely solid nodules in the group of hypoechoic nodules (P=0.063) and in the group of nodules with suspicious US features (P=0.028), but was not significantly different from that of partially cystic nodules regardless of echogenicity or the presence of suspicious US features (P≤0.652). Conclusion: Thyroid nodules with minimal cystic changes have a low risk of malignancy, similar to that of partially cystic nodules regardless of echogenicity or the presence of suspicious US features. The US lexicon could define solid nodules as nodules with purely solid internal content in order to enhance the accuracy of estimated risks of malignancy.
- Subjects
THYROID crisis; DIAGNOSTIC ultrasonic imaging; NODULAR disease; DIAGNOSIS
- Publication
Ultrasonography, 2016, Vol 35, Issue 2, p153
- ISSN
2288-5919
- Publication type
Article
- DOI
10.14366/usg.15070