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- Title
Mutation Status and Immunoglobulin Gene Rearrangements in Patients from Northwest and Central Region of Spain with Chronic Lymphocytic Leukemia.
- Authors
González-Gascón y Marín, I.; Hernández, J. A.; Martín, A.; Alcoceba, M.; Sarasquete, M. E.; Rodríguez-Vicente, A.; Heras, C.; de las Heras, N.; Fisac, R.; García de Coca, A.; de la Fuente, I.; Hernández-Sánchez, M.; Recio, I.; Galende, J.; Martín-Núnez, G.; Alonso, J. M.; Hernández-Rivas, J. M.; González, M.
- Abstract
The aim of this study was to investigate the frequency and mutation status of the immunoglobulin heavy variable chain (IGHV) in a cohort of 224 patients from northwest and central region of Spain diagnosed with chronic lymphocytic leukemia (CLL), and to correlate it with cytogenetic abnormalities, overall survival (OS) and time to first treatment (TTFT). 125 patients had mutated IGHV, while 99 had unmutated IGHV.The most frequently used IGHV family was IGHV3, followed by IGHV1 and IGHV4.The regions IGHV3-30, IGHV1-69, IGHV3-23, and IGHV4-34 were the most commonly used. Only 3.1% of the patients belonged to the subfamily IGHV3-21 and we failed to demonstrate a worse clinical outcome in this subgroup. The IGHV4 family appearedmore frequently withmutated pattern, similar to IGHV3-23 and IGHV3-74. By contrast, IGHV1-69 was expressed at a higher frequency in unmutatedCLLpatients. All the cases fromIGHV3-11 and almost all fromIGHV5-51 subfamily belonged to the groupof unmutated CLL.
- Publication
BioMed Research International, 2014, Vol 2014, p1
- ISSN
2314-6133
- Publication type
Article
- DOI
10.1155/2014/257517