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- Title
Risk of Bacterial Infection in Patients Under Intravenous Iron Therapy: Dose Versus Length of Treatment.
- Authors
Canziani, Maria Eugênia F.; Yumiya, Suely T.; Rangel, Erika B.; Manfredi, Silvia R.; Neto, Miguel Cendoroglo; Draibe, Sergio A.
- Abstract
Abstract: Some studies have suggested that intravenous iron therapy may be associated with an increased risk of infection. We analyzed the incidence of bacterial infection in 111 hemodialysis patients. Group 1 (n = 39, transferrin saturation <20%) received 10 doses of 100 mg of intravenous iron saccharate, 3 doses per week (28 treatment days); Group 2 (n = 13, transferrin saturation <20%) received 20 doses, 3 doses per week (70 treatment days); and Group 3 (n = 59, transferrin saturation 20–50%) received 10 doses, 1 dose per week (70 treatment days). The follow-up was 150 days for all groups, and all infectious episodes were recorded. Pulmonary infection was the most frequent event observed in all of the groups. In an incidence-density analysis, Group 2, which received a total of 20 doses, presented a significantly higher incidence of infection than Group 3, which received only 10 doses over the same period (0.13 versus 0.06 infections per patient per month, p = 0.04). No difference was observed between Groups 1 and 2 suggesting that the risk of infection during iron therapy is dose dependent rather than time length dependent.
- Subjects
BACTERIAL diseases; INTRAVENOUS therapy
- Publication
Artificial Organs, 2001, Vol 25, Issue 11, p866
- ISSN
0160-564X
- Publication type
Article
- DOI
10.1046/j.1525-1594.2001.06894.x