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- Title
Synthesis and Pharmacological Activities of N-(3-Hydroxyphenyl)Benzamide and its 3-O-Derivatives.
- Authors
Abbasi, M. A.; Aziz-ur-Rehman; Irshad, M.; Siddiqui, S. Z.; Ashraf, M.
- Abstract
N-(3-hydroxyphenyl) benzamide (3) was synthesized by the condensation of 3-hydroxyaniline (1) with benzoyl chloride (2) in aqueous medium. From this parent molecule 3, various 3-O-derivatives, 5a-f, were prepared via O-alkylation, by reacting it with different alkyl halides, 4a-f, for 2 h under reflux conditions in the presence of mixture of Na-ethoxide and C2H5OH as solvent. The synthesized compounds were characterized by using different spectroscopic techniques and were subjected to enzyme inhibition activity against butylcholinesterase, acetylcholinesterase, and lipoxygenase enzymes.
- Subjects
BENZAMIDE; AMIDES; CHEMICAL derivatives; HALOALKANES; ACETYLCHOLINESTERASE
- Publication
Pakistan Journal of Chemistry, 2014, Vol 4, Issue 1, p26
- ISSN
2220-2625
- Publication type
Article
- DOI
10.15228/2014.v04.i01.p05