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- Title
Amyloid-β_{42} Plasma Levels are Elevated in Amnestic Mild Cognitive Impairment.
- Authors
Cammarata, Sergio; Borghi, Roberta; Giliberto, Luca; Pardini, Matteo; Pollero, Valeria; Novello, Cristina; Fornaro, Michele; Vitali, Antonella; Bracco, Laura; Caltagirone, Carlo; Bossù, Paola; Odetti, Patrizio; Tabaton, Massimo
- Abstract
Amnestic mild cognitive impairment (aMCI) is considered a prodromal stage of Alzheimer's disease (AD). We measured plasma levels of amyloid-β_{40} (Aβ_{40}) and Aβ_{42} in 191 subjects with aMCI. Seventy-nine of them were clinically followed for two years. In the total cohort of aMCI cases, the average level of Aβ_{42}, as well as the Aβ_{42}/Aβ_{40} ratio, was significantly higher than those of the 102 cognitively normal age-matched subjects. The aMCI cases that converted to probable AD within 2 years had higher levels of Aβ_{42} and, to a lesser extent, Aβ_{40} than the stable cases. However the large variability of measured values indicates that plasma Aβ is not a suitable marker of incipient AD.
- Subjects
COGNITION disorders; ALZHEIMER'S disease; AMYLOID beta-protein; CELL membranes; NEURODEGENERATION
- Publication
Journal of Alzheimer's Disease, 2009, Vol 18, Issue 2, p267
- ISSN
1387-2877
- Publication type
Article
- DOI
10.3233/JAD-2009-1144