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- Title
Increased apoB/A-I ratio independently associated with Type 2 diabetes mellitus: cross-sectional study in a Korean population.
- Authors
Hwang, Y. C.; Ahn, H. Y.; Kim, W. J.; Park, C. Y.; Park, S. W.
- Abstract
Diabet. Med. 29, 1165-1170 (2012) Abstract Aims The aim of this study was to investigate whether increased apolipoprotein B/apolipoprotein A-I ratio is associated with Type 2 diabetes mellitus independent of other risk factors for Type 2 diabetes. Methods A total of 70 063 subjects (41 391 men and 28 672 women; mean age 41.5 years) who visited the Health Screening Center at Kangbuk Samsung Hospital for a routine medical check-up between January 2009 and December 2009 were enrolled in this study. Results The mean apolipoprotein B/apolipoprotein A-I ratio in the study subjects was 0.66 ± 0.18. The prevalence of Type 2 diabetes increased across the apolipoprotein B/apolipoprotein A-I ratio quartiles (1.0%, 1.6%, 2.9%, and 4.8% for the 1st through 4th quartiles, respectively, P < 0.001) and homeostasis model assessment-insulin resistance (HOMA2-IR) also showed an increasing tendency by quartile ( P < 0.001). The apolipoprotein B/apolipoprotein A-I ratio was correlated with age, adiposity, blood pressure, HOMA2-IR value, fasting glucose levels, and other inflammatory marker, including high-sensitivity C-reactive protein, and lipoprotein (a) levels (all P < 0.001). In a multiple logistic regression model, the highest apolipoprotein B/apolipoprotein A-I ratio quartile was associated with Type 2 diabetes, even after controlling for other risk factors for diabetes, such as age, gender, BMI, systolic blood pressure, HOMA2-IR values, high-sensitivity C-reactive protein levels, family history of diabetes, presence of metabolic syndrome, and conventional lipid parameters (odds ratio 1.31; 95% confidence interval 1.17-1.46, P < 0.001). Conclusions The apolipoprotein B/apolipoprotein A-I ratio was found to be associated with Type 2 diabetes independent of other risk factors for diabetes and conventional lipid parameters.
- Subjects
KOREA; TYPE 2 diabetes risk factors; ANALYSIS of triglycerides; APOLIPOPROTEINS; CHI-squared test; EPIDEMIOLOGY; HIGH density lipoproteins; HOMEOSTASIS; LOW density lipoproteins; TYPE 2 diabetes; POPULATION; DATA analysis; CROSS-sectional method; DATA analysis software; DESCRIPTIVE statistics
- Publication
Diabetic Medicine, 2012, Vol 29, Issue 9, p1165
- ISSN
0742-3071
- Publication type
Article
- DOI
10.1111/j.1464-5491.2012.03622.x