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- Title
Surgical Decision Making in the BRCA-Positive Population: Institutional Experience and Comparison with Recent Literature.
- Authors
Flippo‐Morton, Teresa; Walsh, Kendall; Chambers, Karinn; Amacker‐North, Lisa; White, Brook; Sarantou, Terry; Boselli, Danielle M.; White, Richard L.
- Abstract
A retrospective study was performed to document the uptake and extent of surgical intervention in patients with a known mutation in the BRCA1/2 genes and associated outcomes. Data were collected retrospectively on BRCA-positive patients with and without cancer at the time of genetic testing. Our findings were compared to those published in the current literature. Of patients with cancer at testing, 61% chose bilateral mastectomies. Of patients without cancer, 54% chose risk-reducing surgery (RRS) including risk-reducing mastectomy (RRM), risk-reducing salpingo-oophorectomy (RRSO), or both. Time to surgery was significantly shorter to RRSO than to RRM. The literature suggests and our data support that acceptance of RRM in the BRCA-positive population has gradually increased over time. Consistently high rates of RRSO uptake and short intervals from time-of-testing to RRSO demonstrate that RRSO is still more acceptable to this population than RRM.
- Subjects
NORTH Carolina; BREAST tumor prevention; BREAST tumor risk factors; OVARIAN tumors; CANCER treatment; FISHER exact test; GENETIC counseling; MASTECTOMY; GENETIC mutation; OVARIECTOMY; PROBABILITY theory; REGRESSION analysis; SYSTEMATIC reviews; GENETIC testing; SECONDARY analysis; SPECIALTY hospitals; BRCA genes; RETROSPECTIVE studies; DATA analysis software; DESCRIPTIVE statistics; EARLY detection of cancer; SALPINGECTOMY; PATIENT decision making; PREVENTION; TUMOR risk factors
- Publication
Breast Journal, 2016, Vol 22, Issue 1, p35
- ISSN
1075-122X
- Publication type
Article
- DOI
10.1111/tbj.12521