We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Urinary transforming growth factor-β1 in children with obstructive uropathy.
- Authors
ZIEG, JAKUB; BLAHOVA, KVETA; SEEMAN, TOMAS; BRONSKY, JIRI; DVORAKOVA, HANA; PECHOVA, MARTA; JANDA, JAN; MATOUSOVIC, KAREL
- Abstract
ABSTRACT: Aim: Obstructive uropathies (OU) in childhood constitute one of the major causes of chronic renal insufficiency. Transforming growth factor-β1 (TGF-β1) is considered to be the major fibrogenic growth factor. The aim of the present study was to investigate urinary TGF-β1 levels in children with obstructive and non-obstructive uropathies (NOU). Methods: This study involved 19 children with OU, 11 children with non-obstructive hydronephrosis and 21 healthy children. Urinary TGF-β1, proteinuria, microalbuminuria and urinary α1-microglobulin were measured, and renal function was assesed. The results were statistically analyzed. Results: Mean urinary TGF-β1 concentrations in patients with OU were significantly higher than those with NOU (4.14 ± 0.67 creatinine vs 1.80 ± 0.24 pg/mmol creatinine, P < 0.05) and healthy controls (1.66 ± 0.28 pg/mmol creatinine, P < 0.05). Positive correlations of urinary TGF-β1 concentrations with proteinuria ( r = 0.87, P < 0.0001) and urinary α1-microglobulin ( r = 0.82, P = 0.0002) were found in patients with OU. Conclusion: Children with OU have higher urinary TGF-β1 than children with NOU. Urinary TGF-β1 may be a useful non-invasive tool for the differential diagnosis between OU and NOU in children. A positive correlation of TGF-β1 with markers of renal tissue damage in patients with OU was found.
- Subjects
URINARY organ diseases; CHRONIC kidney failure in children; PROTEINURIA in children; ALBUMINURIA; TRANSFORMING growth factors-beta; CREATININE; DISEASE risk factors
- Publication
Nephrology, 2011, Vol 16, Issue 6, p595
- ISSN
1320-5358
- Publication type
Article
- DOI
10.1111/j.1440-1797.2011.01459.x