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- Title
Low muscle mass and sarcopenia: common and predictive of osteopenia in inflammatory bowel disease.
- Authors
Bryant, R. V.; Ooi, S.; Schultz, C. G.; Goess, C.; Grafton, R.; Hughes, J.; Lim, A.; Bartholomeusz, F. D.; Andrews, J. M.
- Abstract
Background Body composition is poorly studied in inflammatory bowel disease ( IBD). Sarcopenia describes a loss of muscle mass and strength. Aim To assess the prevalence of low lean mass ( LM), sarcopenia and associated morbidity in an adult IBD cohort. Methods Cross-sectional data were gathered on pre-menopausal 18- to 50-year-old patients with IBD. Whole-body dual-energy X-ray absorptiometry, anthropometric assessment and grip strength were performed. Low LM was defined as ≥1 s.d. below the population mean for appendicular skeletal muscle index [ ASMI (kg)/height (m)²], and sarcopenia as both ASMI and grip strength ≥1 s.d. below population mean. Multivariate regression analyses were performed. Results Of 137 participants (median age 31 years, BMI 24.8 kg/m2), 56% were male and 69% had Crohn's disease ( CD). Low LM and sarcopenia were observed in 21% and 12% of patients, respectively, and osteopenia/osteoporosis in 38% of patients (mean lumbar spine t-score −0.3 ± s.d. 1.1). Grip strength predicted low LM and sarcopenia better than did body mass index ( BMI) ( OR 4.8 vs. OR 0.7 for low- LM, P < 0.05 both). Normal BMI was falsely reassuring in 72% and 76% of patients with low ASMI and sarcopenia, respectively. Low LM and sarcopenia ( OR = 3.6, P = 0.03; OR = 6.3, P = 0.02; respectively), but not BMI nor fat mass, predicted osteopenia/osteoporosis. Conclusions Low lean mass and sarcopenia are common in patients with IBD, and important to recognise as they predict osteopenia/osteoporosis. Grip strength testing should be incorporated into routine clinical practice to detect low lean mass deficits, which may go unrecognised using BMI alone.
- Subjects
SARCOPENIA; OSTEOPENIA; INFLAMMATORY bowel diseases; MUSCLE strength; MENOPAUSE; SKELETAL muscle
- Publication
Alimentary Pharmacology & Therapeutics, 2015, Vol 41, Issue 9, p895
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1111/apt.13156