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- Title
Factors that affect the diagnostic accuracy of liver fibrosis measurement by Fibroscan in patients with chronic hepatitis B.
- Authors
Kim, S. U.; Seo, Y. S.; Cheong, J. Y.; Kim, M. Y.; Kim, J. K.; Um, S. H.; Cho, S. W.; Paik, S. K.; Lee, K. S.; Han, K.‐H.; Ahn, S. H.
- Abstract
Aliment Pharmacol Ther 2010; 32: 498–505 Background Interquartile range/median value (IQR/M) of liver stiffness measurement (LSM) is a factor in chronic hepatitis C (CHC) leading to over estimation of fibrosis by Fibroscan. Aim To investigate factors that affect the accuracy of LSM in chronic hepatitis B (CHB). Methods One hundred and ninety-nine patients were enrolled. Only procedures yielding ≥10 valid measurements were considered reliable. Liver fibrosis was evaluated using the Batts and Ludwig system. Liver biopsy (LB) specimens <15 mm were considered ineligible. Results The mean age (142 men and 57 women) was 40.1 years. A significant discordance (discordance of at least two stages between LB and LSM) was identified in 38 (19.1%) and 47 (23.6%) patients respectively, according to Marcellin et al. and Chan et al.’s cutoff values. In multivariate analyses, BMI and fibrosis stage (F0–2 vs. F3–4) were identified as independent predictors for significant discordance ( P = 0.040; hazard ratio [HR], 1.126; 95% confidence interval [CI], 1.005–1.261 and P = 0.036; HR, 0.450; 95% CI, 0.213–0.949 respectively) with Marcellin et al.’s cutoffs, whereas fibrosis stage was the only independent predictor ( P = 0.004; HR, 0.300; 95% CI, 0.131–0.685) with Chan’s cutoffs . Conclusions Success rate and IQR/M were not predictive factors of the accuracy for diagnosing liver fibrosis by Fibroscan in CHB. Fibrosis stage (F0-2) was the only factor to predict significant discordance between LB and LSM.
- Subjects
HEPATITIS C; FIBROSIS; LIVER biopsy; MULTIVARIATE analysis; CONFIDENCE intervals
- Publication
Alimentary Pharmacology & Therapeutics, 2010, Vol 32, Issue 3, p498
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1111/j.1365-2036.2010.04353.x