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- Title
Trait Conscientiousness predicts rate of brain atrophy in multiple sclerosis.
- Authors
Fuchs, Tom A; Benedict, Ralph HB; Wilding, Gregory; Wojcik, Curtis; Jakimovski, Dejan; Bergsland, Niels; Ramasamy, Deepa P; Weinstock-Guttman, Bianca; Zivadinov, Robert; Dwyer, Michael G
- Abstract
Background: Conscientiousness is a core personality trait with favorable prognosis in neuropsychiatric disease. Objective: We aimed to determine whether baseline Conscientiousness predicts future brain atrophy in multiple sclerosis (MS) after accounting for demographic and basic clinical characteristics. Methods: Trait Conscientiousness, clinical features, and Expanded Disability Status Scale (EDSS) were obtained at baseline. Lateral ventricle volume (LVV) was measured longitudinally. In a retrospective general linear mixed effects model, data from 424 patients were analyzed (mean 6 time-points, up to 15 years). Results/Conclusion: We observed significant age and Conscientiousness by time-from-baseline interactions indicating that younger age and higher Conscientiousness are associated with reduced progression of brain atrophy.
- Subjects
CEREBRAL atrophy; MULTIPLE sclerosis; CONSCIENTIOUSNESS; PROGNOSIS
- Publication
Multiple Sclerosis Journal, 2020, Vol 26, Issue 11, p1433
- ISSN
1352-4585
- Publication type
Article
- DOI
10.1177/1352458519858605