We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Association between antiphospholipid antibodies and all-cause mortality among end-stage renal disease patients with and without SLE: a retrospective cohort study.
- Authors
Broder, Anna; Mowrey, Wenzhu B.; Kim, Mimi; Murakhovskaya, Irina; Billett, Henny; Neugarten, Joel; Costenbader, Karen H.; Putterman, Chaim
- Abstract
Objective. To investigate the association between the presence of aPL and/or LA and all-cause mortality among end-stage renal disease (ESRD) patients with and without SLE. Methods. We included ESRD patients >18 years old followed at an urban tertiary care centre between 1 January 2006 and 31 January 2014 who had aPL measured at least once after initiating haemodialysis. All SLE patients met ACR/SLICC criteria. APL/LA+was defined as aCL IgG or IgM>40IU, anti-β2glyco-protein1 IgG or IgM>40IU or LA+. Deaths as at 31 January 2014 were captured in the linked National Death Index data. Time to death was defined from the first aPL measurement. Results. We included 34 SLE ESRD and 64 non-SLE ESRD patients; 30 patients died during the study period. SLE ESRD patients were younger [40.4 (12.5) vs 51.9(18.1) years, P = 0.001] and more were women (88.2% vs 54.7%, P<0.001) vs non-SLE ESRD patients. The frequency of aPL/LA+was 24% in SLE and 13% in non-SLE ESRD (P = 0.16). Median (inter-quartile range) follow-up time was 1.6 (0.3-3.5) years in SLE and 1.4 (0.4-3.2) years in non-SLE, P = 0.74. The adjusted hazard ratio (HR) for all-cause mortality for SLE patients who were aPL/LA+vs aPL/LA- was 9.93 (95% CI 1.33, 74.19); the adjusted HR for non-SLE aPL/LA+vs aPL/LA- was 0.77 (95% CI 0.14, 4.29). Conclusion. SLE ESRD patients with aPL/LA+ had higher all-cause mortality risk than SLE ESRD patients without these antibodies, while the effects of aPL/LA on mortality were comparable among non-SLE ESRD patients.
- Subjects
NEW York (State); MORTALITY risk factors; AUTOANTIBODIES; CHRONIC kidney failure; CONFIDENCE intervals; HOSPITALS; SURVIVAL analysis (Biometry); SYSTEMIC lupus erythematosus; PROPORTIONAL hazards models; RETROSPECTIVE studies; DATA analysis software; DESCRIPTIVE statistics; KAPLAN-Meier estimator; LOG-rank test; MANN Whitney U Test
- Publication
Rheumatology, 2016, Vol 55, Issue 5, p817
- ISSN
1462-0324
- Publication type
Article
- DOI
10.1093/rheumatology/kev423