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- Title
Calpain-10 and Adiponectin Gene Polymorphisms in Korean Type 2 Diabetes Patients.
- Authors
Ji Sun Nam; Jung Woo Han; Sang Bae Lee; Ji Hong You; Min Jin Kim; Shinae Kang; Jong Suk Park; Chul Woo Ahn
- Abstract
Background: Genetic variations in calpain-10 and adiponectin gene are known to influence insulin secretion and resistance in type 2 diabetes mellitus. Recently, several single nucleotide polymorphisms (SNPs) in calpain-10 and adiponectin gene have been reported to be associated with type 2 diabetes and various metabolic derangements. We investigated the associations between specific calpain- 10 and adiponectin gene polymorphisms and Korean type 2 diabetes patients. Methods: Overall, 249 type 2 diabetes patients and 131 non-diabetic control subjects were enrolled in this study. All the subjects were genotyped for SNP-43 and -63 of calpain-10 gene and G276T and T45G frequencies of the adiponectin gene. The clinical characteristics and measure of glucose metabolism were compared within these genotypes. Results: Among calpain-10 polymorphisms, SNP-63 T/T were more frequent in diabetes patients, and single SNP-63 increases the susceptibility to type 2 diabetes. However, SNP-43 in calpain-10 and T45G and intron G276T in adiponectin gene were not significantly associated with diabetes, insulin resistance, nor insulin secretion. Conclusion: Variations in calpain-10, SNP-63 seems to increase the susceptibility to type 2 diabetes in Koreans while SNP-43 and adiponectin SNP-45, -276 are not associated with impaired glucose metabolism.
- Subjects
CALPAIN; ADIPONECTIN; GENETICS of type 2 diabetes
- Publication
Endocrinology & Metabolism, 2018, Vol 33, Issue 3, p364
- ISSN
2093-596X
- Publication type
Article
- DOI
10.3803/EnM.2018.33.3.364