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- Title
Two-year follow-up of children with congenital Zika syndrome: the evolution of clinical patterns.
- Authors
Rua, Erica Conti; de Oliveira, Solange Artimos; de Oliveira Vianna, Renata Artimos; Dalcastel, Luis Antonio Bataglin; de Castro Sarmet dos Santos, Teresa Cristina; Cardoso, Claudete Aparecida Araújo; Fernandes, Alexandre Ribeiro
- Abstract
The aim of the study was to describe neurological manifestations in children with congenital Zika syndrome (CZS) in the first 2 years of age. In this prospective observational study, children with CZS treated at a university hospital received a neurological assessment and were evaluated using two neurodevelopmental scales (the Denver II test and the assessment of gross motor development of the World Health Organization) by a pediatric neurologist on admission to the study and at 4, 8, 12, 18, and 24 months of age. The data collected were stored in Microsoft Excel version 14.6.3. Thirty-eight children (27 males and 11 females; a median age of 4.3 months (interquartile range (IQR): 1.6–11.4)) with CZS were evaluated. Irritability was present in 50% and 27% of the children at 8 months and 24 months, respectively. Axial hypertonia was highly prevalent at 4 months (77%), with a decrease to 50% at 24 months. At all ages, spastic tetraparesis was the most common motor abnormality (> 80%). Twenty-seven (71%) participants were diagnosed with epilepsy, and the median age at seizure onset was 6 months (IQR: 3.5–8). The most frequent types of seizures were focal seizures and spasms, with spasms being the most frequent in the first year of life (52%) and focal crises being the most frequent in the second year of life (50%). Conclusion: This study allowed observation of neurological abnormalities over time, the evolution of epileptic manifestations, and recognition of new patterns of clinical neurological abnormalities, helping clinicians to recognize CZS earlier, minimizing the impact of new outbreaks. What is Known: • Clinical patterns of SZC patients at pre-established ages or date of data collection • More frequent studies with data collection of clinical-radiological features of patient's over his first year of life What is New: • Comprehensive clinical neurological progression data regarding CZS in the first 2 years of life, recognizing patterns • Hypothesis including a new CZS spectrum with milder clinical-radiological features
- Subjects
SCIENTIFIC observation; ACADEMIC medical centers; INFANTILE spasms; AGE distribution; EPILEPSY; NEUROLOGIC manifestations of general diseases; NEURAL development; DENVER Developmental Screening Test; DESCRIPTIVE statistics; ZIKA virus infections; QUADRIPLEGIA; SEIZURES (Medicine); DATA analysis software; LONGITUDINAL method; NEUROLOGIC examination
- Publication
European Journal of Pediatrics, 2022, Vol 181, Issue 3, p991
- ISSN
0340-6199
- Publication type
Article
- DOI
10.1007/s00431-021-04280-z