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- Title
Variables related to chronic immune thrombocytopenia: experience from a single center and comparison to a meta-analysis.
- Authors
Fernández-Plaza, S.; González de Pablo, J.; Gálvez, E.; Zubicaray, J.; Guillén, M.; Sevilla, J.; Sebastián, E.
- Abstract
Classically, several variables have been related to the disease course of chronic primary immune thrombocytopenia (cITP), though to date, there is no consensus on their clinical relevance. In a recent systematic review, a meta-analysis was made and confirmed the existence of certain cITP-related variables that may be related to prognosis in pediatric patients. We retrospectively analyzed a cohort of patients diagnosed with ITP, identified prognostic variables, and compared our results to the variables described by the authors. A multivariate study revealed that older age at diagnosis and higher platelet count were the only independent variables related to cITP. Children up to age 4 years and those with lower platelet counts (below 20 × 109/L) were at lower risk for cITP. Conclusion: We therefore concluded that only age and platelet count at diagnosis are independent variables that should be considered when evaluating the risk of developing cITP. What is Known: • Around 20% of patients with immune thrombocytopenia progress to chronic disease as determined by a sustained platelet count below 100×109/L for more than 12 months. • A number of variables potentially related to the development of cITP are being studied, such as age, sex, cell count, and previous treatment. What is New: • This is a new group of patients diagnosed with ITP in which the platelet count and age at diagnosis are the only independent variables closely related to cITP. • In this new series, we could not confirm other variables previously related to cITP such as total leukocyte count or the absence of treatment at diagnosis.
- Subjects
IDIOPATHIC thrombocytopenic purpura; PLATELET count; LEUKOCYTE count; CHILD patients; DIAGNOSIS; DISEASE progression
- Publication
European Journal of Pediatrics, 2021, Vol 180, Issue 7, p2075
- ISSN
0340-6199
- Publication type
Article
- DOI
10.1007/s00431-021-03990-8