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- Title
Gadolinium Enhanced MR Coronary Vessel Wall Imaging at 3.0 Tesla.
- Authors
Kelle, Sebastian; Schlendorf, Kelly; Hirsch, Glenn A.; Gerstenblith, Gary; Fleck, Eckart; Weiss, Robert G.; Stuber, Matthias
- Abstract
Purpose. We evaluated the influence of the time between low-dose gadolinium (Gd) contrast administration and coronary vessel wall enhancement (LGE) detected by 3T magnetic resonance imaging (MRI) in healthy subjects and patients with coronary artery disease (CAD). Materials and Methods. Four healthy subjects (4 men, mean age 29 ± 3 years and eleven CAD patients (6 women, mean age 61±10 years) were studied on a commercial 3.0 Tesla (T) whole-body MR imaging system (Achieva 3.0 T; Philips, Best, The Netherlands). T1-weighted inversion-recovery coronary magnetic resonance imaging (MRI) was repeated up to 75 minutes after administration of low-dose Gadolinium (Gd) (0.1 mmol/kg Gd-DTPA). Results. LGE was seen in none of the healthy subjects, however in all of the CAD patients. In CAD patients, fifty-six of 62 (90.3%) segments showed LGE of the coronary artery vessel wall at time-interval 1 after contrast. At time-interval 2, 34 of 42 (81.0%) and at time-interval 3, 29 of 39 evaluable segments (74.4%) were enhanced. Conclusion. In this work, we demonstrate LGE of the coronary artery vessel wall using 3.0 T MRI after a single, low-dose Gd contrast injection in CAD patients but not in healthy subjects. In the majority of the evaluated coronary segments in CAD patients, LGE of the coronary vessel wall was already detectable 30-45 minutes after administration of the contrast agent.
- Subjects
GADOLINIUM; CORONARY arteries; MAGNETIC resonance imaging; CORONARY disease; HEART disease diagnosis; CARDIAC patients; MEDICAL imaging systems; ANGIOGRAPHY; ATHEROSCLEROTIC plaque
- Publication
Cardiology Research & Practice, 2010, p1
- ISSN
2090-8016
- Publication type
Article
- DOI
10.4061/2010/856418