We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Uncovering the Hidden Dangers and Molecular Mechanisms of Excess Folate: A Narrative Review.
- Authors
Fardous, Ali M.; Heydari, Ahmad R.
- Abstract
This review delves into the intricate relationship between excess folate (vitamin B9) intake, especially its synthetic form, namely, folic acid, and its implications on health and disease. While folate plays a pivotal role in the one-carbon cycle, which is essential for DNA synthesis, repair, and methylation, concerns arise about its excessive intake. The literature underscores potential deleterious effects, such as an increased risk of carcinogenesis; disruption in DNA methylation; and impacts on embryogenesis, pregnancy outcomes, neurodevelopment, and disease risk. Notably, these consequences stretch beyond the immediate effects, potentially influencing future generations through epigenetic reprogramming. The molecular mechanisms underlying these effects were examined, including altered one-carbon metabolism, the accumulation of unmetabolized folic acid, vitamin-B12-dependent mechanisms, altered methylation patterns, and interactions with critical receptors and signaling pathways. Furthermore, differences in the effects and mechanisms mediated by folic acid compared with natural folate are highlighted. Given the widespread folic acid supplementation, it is imperative to further research its optimal intake levels and the molecular pathways impacted by its excessive intake, ensuring the health and well-being of the global population.
- Subjects
THERAPEUTIC use of folic acid; FOLIC acid metabolism; FOLIC acid deficiency; CARCINOGENESIS; NEURAL tube defects; NEOPLASTIC cell transformation; FETAL development; DIETARY supplements; DNA methylation; PREGNANCY outcomes; CELLULAR signal transduction; AGING; CHILD psychopathology; FOLIC acid; OXIDOREDUCTASES; PROSTATE tumors; EPIGENOMICS
- Publication
Nutrients, 2023, Vol 15, Issue 21, p4699
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15214699