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- Title
Combined Effects of ESRα DNA Methylation and Progesterone on Glucose Metabolic Disorders: The Henan Rural Cohort Study.
- Authors
Feng, Bo; Wang, Lulu; Wei, Dandan; Huo, Wenqian; Jing, Tao; Wang, Chongjian; Mao, Zhenxing
- Abstract
To explore the independent and combined effects of ESRα methylation and progesterone on impaired fasting glucose (IFG) and type 2 diabetes mellitus (T2DM), a case-control study including 901 subjects was conducted. Generalized linear models were performed to assess the independent and combined effects of ESRα methylation and progesterone on IFG or T2DM. Methylation level of cytosine-phosphoguanine (CpG) 1 in the estrogen receptor α (ESRα) gene was positively related to IFG in both men (odds ratio (OR) (95% confidence interval (CI)): 1.77 (1.05, 3.00)) and postmenopausal women (OR (95% CI): 1.82 (1.09, 3.04)), whereas the association between CpG 1 and T2DM was not significant. Positive associations of progesterone with IFG and T2DM were observed in both men (OR (95% CI): 2.03 (1.18, 3.49) and 3.00 (1.63, 5.52)) and postmenopausal women (OR (95% CI): 2.13 (1.27, 3.56) and 3.30 (1.85, 5.90)). Participants with high CpG 1 methylation plus high progesterone had an increased risk of IFG and T2DM, both in men and postmenopausal women. ESRα methylation and progesterone were positively associated with IFG, and the positive association between progesterone and T2DM was also found. Importantly, we firstly found the combined effects of ESRα methylation and progesterone on IFG and T2DM.
- Subjects
CHINA; PROGESTERONE; CONFIDENCE intervals; RURAL conditions; GLUCOSE metabolism disorders; BLOOD sugar; CASE-control method; ESTROGEN receptors; DNA methylation; TREATMENT effectiveness; TYPE 2 diabetes; POSTMENOPAUSE; RESEARCH funding; COMBINED modality therapy; ODDS ratio; LONGITUDINAL method
- Publication
Nutrients, 2023, Vol 15, Issue 7, p1659
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15071659