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- Title
Effects of High and Low Protein Diets on Inflammatory Profiles in People with Morbid Obesity: A 3-Week Intervention Study.
- Authors
Koelman, Liselot; Markova, Mariya; Seebeck, Nicole; Hornemann, Silke; Rosenthal, Anke; Lange, Volker; Pivovarova-Ramich, Olga; Aleksandrova, Krasimira
- Abstract
Nutritional interventions in morbidly obese individuals that effectively reverse a pro-inflammatory state and prevent obesity-associated medical complications are highly warranted. Our aim was to evaluate the effect of high (HP) or low (LP) protein diets on circulating immune-inflammatory biomarkers, including C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-a), interleukin-10 (IL-10), monocyte chemoattractant protein-1 (MCP-1), chemerin, omentin, leptin, total adiponectin, high molecular weight adiponectin, and fetuin-A. With this aim, 18 people with morbid obesity were matched into two hypocaloric groups: HP (30E% protein, n = 8) and LP (10E% protein, n = 10) for three weeks. Biomarkers were measured pre and post intervention and linear mixed-effects models were used to investigate differences. Consuming HP or LP diets resulted in reduced CRP (HP: −2.2 ± 1.0 mg/L, LP: −2.3 ± 0.9 mg/L) and chemerin (HP: −17.9 ± 8.6 ng/mL, LP: −20.0 ± 7.4 ng/mL), with no statistically significant differences by diet arm. Participants following the LP diet showed a more pronounced decrease in leptin (−19.2 ± 6.0 ng/mL) and IL-6 (−0.4 ± 0.1 pg/mL) and an increase in total adiponectin (1.6 ± 0.6 µg/mL). Changes were also observed for the remaining biomarkers to a smaller degree by the HP than the LP hypocaloric diet, suggesting that a LP hypocaloric diet modulates a wider range of immune inflammatory biomarkers in morbidly obese individuals.
- Subjects
BIOMARKERS; C-reactive protein; DIET in disease; DIET therapy; HIGH-protein diet; INFLAMMATORY mediators; INTERLEUKINS; DIETARY proteins; REDUCING diets; TUMOR necrosis factors; LEPTIN; MORBID obesity; RANDOMIZED controlled trials; TREATMENT effectiveness; PRE-tests &; post-tests; ADIPONECTIN; STATISTICAL models; DESCRIPTIVE statistics; CHEMERIN
- Publication
Nutrients, 2020, Vol 12, Issue 12, p3636
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu12123636