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- Title
Association between Serum Zinc Levels and Clinical Index or the Body Composition in Incident Hemodialysis Patients.
- Authors
Toida, Tatsunori; Toida, Reiko; Ebihara, Shou; Takahashi, Risa; Komatsu, Hiroyuki; Uezono, Shigehiro; Sato, Yuji; Fujimoto, Shouichi
- Abstract
Background: The relationships between serum zinc levels and body composition or clinical outcomes of incident hemodialysis (HD) patients remain unclear. Methods: This prospective observational study examined the relationships between serum zinc levels and clinical indexes, including body composition, in 142 incident HD patients using a bioelectrical impedance analysis. Patients were divided into three groups according to baseline serum zinc levels: tertile, <45, 45–59, and ≥60 µg/dL. The reference group was set as ≥60 µg/dL. Cox's regression analysis was performed to investigate the relationships between serum zinc categories and cardiovascular events and all-cause mortality after adjustments for potential confounders. Results: Serum zinc levels positively correlated with the nutritional index and negatively correlated with fluid volume markers. In a mean follow-up of 2.5 years, there were 20 cases of cardiovascular events and 15 of all-cause mortality. In the Cox's regression analysis for cardiovascular events and all-cause mortality, the hazard ratio increased with a decrease in serum zinc levels, but was not significant. Conclusion: Serum zinc levels were associated with nutritional and fluid volume markers in incident HD patients. To clarify the relationship between serum zinc levels and cardiovascular events or mortality, further studies with a larger number of cases will be necessary.
- Subjects
BODY composition; CARDIOVASCULAR system abnormalities; HEMODIALYSIS; BIOELECTRIC impedance; LONGITUDINAL method; NUTRITION; SCIENTIFIC observation; REGRESSION analysis; ZINC; TREATMENT effectiveness; NUTRITIONAL status; ODDS ratio
- Publication
Nutrients, 2020, Vol 12, Issue 10, p3187
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu12103187