We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Selenium Supplementation and Prostate Health in a New Zealand Cohort.
- Authors
Karunasinghe, Nishi; Ng, Lance; Wang, Alice; Vaidyanathan, Venkatesh; Zhu, Shuotun; Ferguson, Lynnette R.
- Abstract
Background: There is variable reporting on the benefits of a 200 μg/d selenium supplementation towards reducing prostate cancer impacts. The current analysis is to understand whether stratified groups receive supplementation benefits on prostate health. Methods: 572 men were supplemented with 200 µg/d selenium as selinized yeast for six months, and 481 completed the protocol. Selenium and prostate-specific antigen (PSA) levels were measured in serum at pre- and post-supplementation. Changes in selenium and PSA levels subsequent to supplementation were assessed with and without demographic, lifestyle, genetic and dietary stratifications. Results: The post-supplementation selenium (p = 0.002) and the gain in selenium (p < 0.0001) by supplementation were significantly dependent on the baseline selenium level. Overall, there was no significant correlation between changes in PSA and changes in selenium levels by supplementation. However, stratified analyses showed a significant inverse correlation between changes in PSA and changes in selenium in men below the median age (p = 0.048), never-smokers (p = 0.031), men carrying the GPX1 rs1050450 T allele (CT, p = 0.022 and TT, p = 0.011), dietary intakes above the recommended daily intake (RDI) for zinc (p < 0.05), and below the RDI for vitamin B12 (p < 0.001). Conclusions: The current analysis shows the influence of life factors on prostate health benefits of supplemental selenium.
- Subjects
PROSTATE physiology; AGE distribution; ALLELES; STATISTICAL correlation; DIETARY supplements; HEALTH status indicators; LONGITUDINAL method; NUTRITIONAL requirements; PROSTATE tumors; SELENIUM; VITAMIN B12; ZINC; PROSTATE-specific antigen; LIFESTYLES; PRE-tests &; post-tests; GENOTYPES; DISEASE complications
- Publication
Nutrients, 2020, Vol 12, Issue 1, p2
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu12010002