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- Title
Anti-Inflammatory Activity of Isomaltodextrin in a C57BL/6NCrl Mouse Model with Lipopolysaccharide-Induced Low-Grade Chronic Inflammation.
- Authors
Hann, Melissa; Zeng, Yuhan; Zong, Lingzi; Sakurai, Takeo; Taniguchi, Yoshifumi; Takagaki, Ryodai; Watanabe, Hikaru; Mitsuzumi, Hitoshi; Mine, Yoshinori
- Abstract
The purpose of this study was to identify the anti-inflammatory activity and mechanism of isomaltodextrin (IMD) in a C57BL/6NCrl mouse model with lipopolysaccharide (LPS)-induced systemic low-grade chronic inflammation and the effect on inflammation-induced potential risk of metabolic disorders. Pre-treatment of IMD decreased the production of pro-inflammatory mediators, TNF-α and MCP-1, and stimulated the production of the anti-inflammatory mediator, adiponectin by increasing the protein expression of peroxisome proliferator-activated receptor gamma (PPAR-γ) in the white adipose tissues. IMD administration reduced plasma concentrations of endotoxin, decreased macrophage infiltration into adipocytes, and increased expression of mucin 2, mucin 4, and the tight junction protein claudin 4. These results suggest that IMD administration exerted an anti-inflammatory effect on mice with LPS-induced inflammation, potentially by decreasing circulating endotoxin, suppressing pro-inflammatory mediators and macrophage infiltration, or by improving mucus or tight junction integrity. IMD exerted protein expression of insulin receptor subset-1 (IRS-1). IMD alleviated the disturbance of gut microflora in LPS-treated mice, as the number of B. bifidum, L. casei, and B. fragilis increased, and E. coli and C. difficile decreased, when compared to LPS-treated mice. The analysis of short chain fatty acids (SCFAs) further supported that the concentrations of acetic and butyric acids were positively correlated with IMD, as well as the number of beneficial bacteria. This study provides evidence that IMD possesses anti-inflammatory properties and exerts beneficial functions to prevent systemic low-grade chronic inflammation and reduces the risk of developing insulin resistance and associated metabolic diseases.
- Subjects
ANTI-inflammatory agents; ADIPOSE tissues; ANIMAL experimentation; ENDOTOXINS; FAT cells; DIETARY fiber; GENE expression; GLUCANS; INFLAMMATION; METABOLIC disorders; MICE; TUMOR necrosis factors; GUT microbiome; ADIPONECTIN; LIPOPOLYSACCHARIDES; PEROXISOME proliferator-activated receptors; PHARMACODYNAMICS
- Publication
Nutrients, 2019, Vol 11, Issue 11, p2791
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu11112791