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- Title
Genotoxic and antiproliferative potential of extracts of Echinodorus grandiflorus and Sagittaria montevidensis (Alismataceae).
- Authors
Coelho, Ana Paula Durand; Laughinghouse, Haywood Dail; Kuhn, Andrielle Wouters; Boligon, Aline Augusti; Canto-Dorow, Thais Scotti do; Silva, Antonio Carlos Ferreira da; Tedesco, Solange Bosio
- Abstract
The economic potential of the germplasm of medicinal species is a rich resource that should be preserved and used. The medicinal speciesEchinodorus grandiflorusandSagittaria montevidensisbelong to the family Alismataceae. Depurative, diuretic, anti-inflammatory, antivenin, and anti-rheumatic actions have been associated withE. grandiflorus, where the leaves are the main part used.Sagittaria montevidensisdoes not yet have its medicinal properties known and has a wide morphological variability, and is sometimes confused withE. grandiflorus. The present study aimed to evaluate the genotoxic and antiproliferative potential of extracts of dry leaves ofE. grandiflorusandS. montevidensison the cell cycle ofAllium cepa, as well as undertake analysis by high performance liquid chromatography (HPLC-DAD) for the quantification of the compounds from the extracts.A. cepabulb rootlets were submitted to the extracts for 24 h, prepared from plant material at two concentrations, 6 g dm−3and 24 g dm−3for each species, and two controls. Afterwards, the analysis of cell division and calculation of the mitotic index was undertaken. Part of the extracts was analyzed by HPLC-DAD. The results differed significantly between the controls and the treatments of both groups; the species did not have antimutagenic activity. The phytochemical analysis presented higher levels of caffeic acid and flavonoid glycoside inE. grandiflorusand phenolic glycoside inS. montevidensis.This study showed that the extracts ofE. grandiflorusandS. montevidensiscontain genotoxic potential and when used in high concentrations, anti-proliferative potential. HPLC-DAD revealed flavonoids and phenolic acids for both species.
- Publication
Caryologia, 2017, Vol 70, Issue 1, p82
- ISSN
0008-7114
- Publication type
Article
- DOI
10.1080/00087114.2016.1275932