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- Title
The Impact of Fibrinogen to Prognostic Nutritional Index Rate on Prognosis of Pancreatic Ductal Adenocarcinoma.
- Authors
Igarashi, Yosuke; Shirai, Yoshihiro; Tanji, Yoshiaki; Hamura, Ryoga; Yanagaki, Mitsuru; Abe, Kyohei; Onda, Shinji; Furukawa, Kenei; Matsumoto, Michinori; Tsunematsu, Masashi; Ikegami, Toru
- Abstract
Introduction: The aim of the present study was to evaluate the prognostic value of the ratio of serum fibrinogen to prognostic nutritional index (PNI; Fbg/PNI) in patients undergoing resection for pancreatic ductal adenocarcinoma. Methods: A total of 140 patients who had undergone resection for pancreatic cancer were included. Patients were divided into two groups according to a Fbg/PNI ≥8.8 or <8.8. Survival data were analyzed using the log-rank test for univariate analysis and Cox proportional hazards for multivariate analysis. Results: Fbg/PNI was a significant prognostic indicator in univariate analysis for overall survival (OS) and disease-free survival (DFS). Fbg/PNI retained significance in multivariate analysis for OS (hazard ratio, 1.81; 95% confidence interval, 1.19-2.77; P <.01) in addition to tumor differentiation and nodal involvement. Fbg/PNI was a significant independent prognostic indicator of poor DFS on multivariate analysis (hazard ratio, 1.54; 95% confidence interval, 1.05-2.26; P =.03). Conclusion: Preoperative Fbg/PNI is a novel significant independent prognostic indicator for OS and DFS following resection of pancreatic cancer with curative intent.
- Subjects
PANCREATIC duct; FIBRINOGEN; MULTIVARIATE analysis; PROGNOSIS; PROGRESSION-free survival; PANCREATIC intraepithelial neoplasia; PANCREATIC tumors
- Publication
American Surgeon, 2023, Vol 89, Issue 11, p4255
- ISSN
0003-1348
- Publication type
Article
- DOI
10.1177/00031348231204912