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- Title
IN VITRO ANTI-CANDIDA ACTIVITY OF SALSOLA RIGIDA.
- Authors
Seifi, Zahra; Seifi, Fatemeh; Mahdavi, Mohammad Javad; Seifi, Raheleh; Mahmoudabadi, Ali Zarei
- Abstract
Background and Objectives: The last four decades have witnessed a dramatic increase in the incidence of candidemia and invasive candidiasis, originating in tertiary care centers and now observed in virtually all type hospitals. The spread of resistance to current antifungal drugs and reduced number of drugs available makes it necessary to discover new antifungal drugs and compounds. Traditional medicine is a potential source of new antifungal. Salsola rigida is one of the highly qualitative native species of arid and semi-arid regions of the country. It belongs to the family of Chenopodiaceae. S. rigida is a traditional herbal medicine that it is useful for diseases such as hypertension and leprosy. The aim of study was to assess in vitro anti-Candida activity of the ethnologic extract of S. rigida. Materials and Methods: The aerial parts of S. rigida were collected and its identification was verified. In this study, the Minimum Inhibitory Concentration (MIC) of the ethnologic extract of S. rigida in the concentrations of 25-400 mgml-1 evaluated against various Candida spp collected of urine and vaginitis (Candida glabrata, C. albicans, C. dubliniensis, C. kefyer, C. tropicalis and C. humicola) using the agar well diffusion method. Results: It was found that the ethnologic extract from the aerial parts of S. rigida was exhibited anti- Candida activity by ranges of inhibition zones 1-2. 4mm and MIC by ranges of 100-400 mg ml-1. Conclusion: S. rigida that showed the anti-Candida activity is the worth of further investigations in order to identify the active compounds and their clinical applications for the treatment of candidiasis.
- Subjects
CANDIDA; SALSOLA; CHENOPODIACEAE; CANDIDIASIS; BOTANICAL fungicides; HERBAL medicine; HYPERTENSION
- Publication
Jundishapur Journal of Microbiology, 2013, p5
- ISSN
2008-3645
- Publication type
Article