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- Title
The role of inflammation in atherothrombosis: implications for clinical practice.
- Authors
Tedgui, Alain
- Abstract
Inflammation plays a key role in atherothrombosis: in the development of plaques, plaque rupture and thrombus formation. Various biochemical substances have been shown to be involved in the inflammatory process, some with proinflammatory activity and others with anti-inflammatory activity. Increased expression of many inflammatory mediators (e.g. C-reactive protein, CD40 ligand, P-selectin and IL-6) has been shown to correlate with increased risk of atherothrombotic events. One possible strategy for primary and secondary prevention is likely to focus on minimizing the inflammatory response and tipping the balance in favour of antiinflammatory mediators and, therefore, plaque stability.
- Subjects
INFLAMMATION; THROMBOSIS; ATHEROSCLEROTIC plaque; ANTI-inflammatory agents; C-reactive protein
- Publication
Vascular Medicine, 2005, Vol 10, Issue 1, p45
- ISSN
1358-863X
- Publication type
Article
- DOI
10.1191/1358863x05vm589ra