We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Long-term survival in primary CNS lymphoma treated by high-dose methotrexate monochemotherapy: role of STAT6 activation as prognostic determinant.
- Authors
Seung-Ho Yang; Kun Lee; Il Kim; Jae Hong; Jae Sung; Byung Son; Sang Lee; Yong-Kil Hong
- Abstract
Abstract We report a single-center experience of 16 immunocompetent patients diagnosed with primary central nervous system lymphoma and treated with monochemotherapy with high-dose methotrexate (MTX) and deferred radiotherapy. MTX was given at a dose of 8.0 g/m2 for induction and at a dose of 3.5–8.0 g/m2 for maintenance. There were eight complete responses (CR), one partial response, one stable disease, and six patients whose tumors progressed in spite of the chemotherapy. At final follow-up, five of five CRs were alive and well without radiotherapy, with median follow-up of 26 months. Overall survival in eight non-CRs treated with the subsequent radiotherapy was 36 months. In the immunohistochemical study, STAT6 was positively expressed in 8 out of 13 cases. They included all non-CRs and two CRs. This observation suggests that STAT6 expression can be used as a prognostic determinant for MTX chemotherapy.
- Subjects
CENTRAL nervous system tumors; DOSE-effect relationship in pharmacology; METHOTREXATE; CANCER chemotherapy; IMMUNOHISTOCHEMISTRY; LYMPHOMA treatment; TUMOR treatment
- Publication
Journal of Neuro-Oncology, 2009, Vol 92, Issue 1, p65
- ISSN
0167-594X
- Publication type
Article
- DOI
10.1007/s11060-008-9736-9