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- Title
Comparison of 6-month outcomes of sepsis versus non-sepsis critically ill patients receiving mechanical ventilation.
- Authors
Hodgson, Carol L.; Higgins, Alisa M.; Bailey, Michael; Barrett, Jonathon; Bellomo, Rinaldo; Cooper, D. James; Gabbe, Belinda J.; Iwashyna, Theodore; Linke, Natalie; Myles, Paul S.; Paton, Michelle; Philpot, Steve; Shulman, Mark; Young, Meredith; Serpa Neto, Ary; PREDICT Study Investigators
- Abstract
<bold>Background: </bold>Data on long-term outcomes after sepsis-associated critical illness have mostly come from small cohort studies, with no information about the incidence of new disability. We investigated whether sepsis-associated critical illness was independently associated with new disability at 6 months after ICU admission compared with other types of critical illness.<bold>Methods: </bold>We conducted a secondary analysis of a multicenter, prospective cohort study in six metropolitan intensive care units in Australia. Adult patients were eligible if they had been admitted to the ICU and received more than 24 h of mechanical ventilation. There was no intervention.<bold>Results: </bold>The primary outcome was new disability measured with the WHO Disability Assessment Schedule 2.0 (WHODAS) 12 level score compared between baseline and 6 months. Between enrollment and follow-up at 6 months, 222/888 (25%) patients died, 100 (35.5%) with sepsis and 122 (20.1%) without sepsis (P < 0.001). Among survivors, there was no difference for the incidence of new disability at 6 months with or without sepsis, 42/106 (39.6%) and 106/300 (35.3%) (RD, 0.00 (- 10.29 to 10.40), P = 0.995), respectively. In addition, there was no difference in the severity of disability, health-related quality of life, anxiety and depression, post-traumatic stress, return to work, financial distress or cognitive function.<bold>Conclusions: </bold>Compared to mechanically ventilated patients of similar acuity and length of stay without sepsis, patients with sepsis admitted to ICU have an increased risk of death, but survivors have a similar risk of new disability at 6 months. Trial registration NCT03226912, registered July 24, 2017.
- Subjects
INTENSIVE care units; RESEARCH; RESEARCH methodology; EVALUATION research; SEPSIS; CATASTROPHIC illness; ARTIFICIAL respiration; COMPARATIVE studies; QUALITY of life; LONGITUDINAL method; DISEASE complications
- Publication
Critical Care, 2022, Vol 26, Issue 1, p1
- ISSN
1364-8535
- Publication type
journal article
- DOI
10.1186/s13054-022-04041-w