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- Title
Efficient Domino Synthesis of Pyrrole-Fused Isocoumarins with Microwave Heating.
- Authors
Sun, Mu‐Yan; Meng, Xiao‐Yan; Zhao, Fu‐Jie; Dang, Yi‐Jing; Jiang, Fei; Liu, Kai; Wang, Cong‐Shuai; Jiang, Bo; Tu, Shu‐Jiang
- Abstract
A new three-component approach to polyfunctionalized isochromeno[4,3- b]pyrroles has been developed with excellent regioselectivity. During these domino reactions, two ring-opening and three cyclization reactions were readily achieved through carbon-carbon bond cleavage under transition-metal-free conditions. The advantages of atom and step economy, and scope make this reaction a powerful tool for assembling tri-heterocyclic scaffolds of general chemical and biomedical interest.
- Subjects
PYRROLES; CHEMICAL synthesis; CARBON-carbon bonds synthesis; HETEROCYCLIC compounds synthesis; CHEMICAL reactions; CHEMICAL processes
- Publication
European Journal of Organic Chemistry, 2014, Vol 2014, Issue 17, p3690
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201402164