We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Prostate motion during radiotherapy of prostate cancer patients with and without application of a hydrogel spacer: a comparative study.
- Authors
Juneja, Prabhjot; Kneebone, Andrew; Booth, Jeremy T.; Thwaites, David I.; Kaur, Ramandeep; Colvill, Emma; Ng, Jin A.; Keall, Paul J.; Eade, Thomas
- Abstract
<bold>Background and Purpose: </bold>The use of a tissue expander (hydrogel) for sparing of the rectum from increased irradiation during prostate radiotherapy is becoming popular. The goal of this study is to investigate the effect of a tissue expander (hydrogel) on the intrafraction prostate motion during radiotherapy.<bold>Methods and Material: </bold>Real time prostate motion was analysed for 26 patients and 742 fractions; 12 patients with and 14 patients without hydrogel (SpaceOAR™). The intra-fraction motion was quantified and compared between the two groups.<bold>Results: </bold>The average (±standard deviation) of the mean motion during the treatment for patients with and without hydrogel was 1.5 (±0.8 mm) and 1.1 (±0.9 mm) respectively (p < 0.05). The average time of motion >3 mm for patients with and without hydrogel was 7.7 % (±1.1 %) and 4.5 % (±0.9 %) respectively (p > 0.05). The hydrogel age, fraction number and treatment time were found to have no effect (R (2) < 0.05) on the prostate motion.<bold>Conclusions: </bold>Differences in intrafraction motion in patients with hydrogel and without hydrogel were within measurement uncertainty (<1 mm). This result confirms that the addition of a spacer does not negate the need for intrafraction motion management if clinically indicated.
- Subjects
PROSTATE cancer treatment; TISSUE expansion; CANCER radiotherapy; HYDROGELS; ONCOLOGY; MEDICAL research; CLINICAL trials; COMPARATIVE studies; DIAGNOSTIC imaging; PHARMACEUTICAL gels; RESEARCH methodology; MEDICAL cooperation; COMPUTERS in medicine; MOTION; PROSTATE tumors; RADIOTHERAPY; RESEARCH; EVALUATION research; EQUIPMENT &; supplies
- Publication
Radiation Oncology, 2015, Vol 10, Issue 1, p1
- ISSN
1748-717X
- Publication type
journal article
- DOI
10.1186/s13014-015-0526-1